pierre on July 28, 2011

Alpha lipoic acid (ALA) has been shown experimentally to be a universally soluble and powerful antioxidant, as well as a “rejuvenator” of other antioxidants. This means that the compound is able to mop up damaging free radicals in its own right and improve the efficiency of other antioxidants that are part of the body’s defense system. One area of the body that shows obvious signs of deterioration due to the action of free radicals is the skin. For this reason alone, ALA should be part of everyone’s skin-care regime.

We take for granted that, as we age, our skin becomes inflexible, less supple, and, consequently, wrinkled. Part of the reason for this is the process of glycation, in which an excess of glucose in our system reacts with proteins like collagen to make them less functional. Alpha lipoic acid, because of its role in glucose metabolism, has been shown to be able to reduce the extent of glycation that occurs, and thus, theoretically, to preserve the skin’s flexibility.

It has also been claimed that abundant levels of alpha lipoic acid in skin tissue will optimize skin health by maximizing cell efficiency and energy production.

For all the above reasons, alpha lipoic acid is currently being touted as an exciting new skin-care solution. At this stage, there is not a lot of clinical data to support the claim, but the limited research available and anecdotal evidence do support the theoretical arguments.

One study showed that mild-to-moderate wrinkles were reduced by up to 50 percent, and also that fine lines were significantly reduced. Another study reported that alpha lipoic acid was responsible for improving the appearance of a type of scarring. A further benefit was that ALA proved to be less irritating to the skin than some other currently used treatments. It should be noted that there was a significant variation in effectiveness between subjects in both trials, so alpha lipoic acid will not be a miracle cure for everybody.

Alpha lipoic acid has been directly linked to skin care as a primary antioxidant that prevents aging and inflammation. Contained in many brands of skin products, this powerful metabolic natural substance has many benefits for skin care, including energy production in skin cells; regeneration of vitamins C and E; inhibiting of the activation of transcription factor NF-kB; reduction of cellular inflammation; stimulation of AP-1, which helps remodel collagen; and protection of the skin from free radical inflammation, including sun exposure.

Universal Antioxidant

The metabolic antioxidant alpha lipoic acid is often called “the universal antioxidant” because it is soluble both in water and in fat. It is 400 times stronger than vitamins E and C combined. What is perhaps the most valuable property of this substance is its ability to penetrate the skin’s surface and the skin cell membrane. Consequently, alpha lipoic acid benefits both the inside and outside of the skin cell.

The production of energy in an enzyme system is called the quruvate dehydrogenase complex, a process which produces energy. The higher the energy levels of a cell, the more youthful the skin remains. In this way, alpha lipoic acid aids cellular metabolism in addition to protecting the skin against free radicals.

Healthy Fat Protection

Polyunsaturated fats, the healthy kind that skin needs to remain young-looking, is protected from free radicals by alpha lipoic acid, which captures the free radicals before they have a chance to enter the cell plasma membrane. This process prevents a very dangerous formation of oxidized fats called lipid peroxides, which damage DNA and activate NF-kB, a proinflammatory cursor to cytokines, such as tumor nectosis factor alpha and interleukins. This kind of deadly damage to DNA transcription, or allowing DNA to give instructions to the cell, is to be avoided at all costs.

Cosmetic Properties

Alpha lipoic acid also has the ability to smooth skin by increasing its exfoliating capacity, or the removal of dead skin cells from the skin’s surface. In addition, this potent little antioxidant regulates the production of oil glands, as under or overproduction can clog pores. It also helps with puffy eyes and helps reduce lines and wrinkles. Skin color is enhanced, and pore size is minimized to give the skin a more polished look. Lastly, alpha lipoic acid was shown to decrease scar tissue in a study performed by Dr. David Genecdov of the International Craniofacial Institute in Dallas, Texas.

Dr. Nicholas Perricone recommends taking alpha lipoic acid internally at the rate of 300 milligrams per day and applying it topically on the face and body. A myriad of skin lotions and creams is available, both in department stores and in health food stores. Often, creams and lotions are sold with alpha lipoic acid in combination with vitamin C Ester and DMAE, a neurochemical that has a tightening effect on the skin.

History and Misconceptions

In the cells of the body, alpha-lipoic acid is converted into dihydrolipoic acid. Alpha-lipoic acid is not the same as alpha linolenic acid, which is an omega-3 fatty acid that contributes to the health of the heart.

Scientists first discovered the relevance of alpha-lipoic acid in the 1950s, and recognized it as an antioxidant in 1988. According to the University of California at Berkeley’s Wellness Guide to Dietary Supplements, alpha-lipoic acid acts as an antioxidant only when there is an excess of it and it is in the “free” state in the cells. There is little free alpha-lipoic acid circulating in your body, unless you consume supplements or get injections.

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pierre on July 28, 2011

Many of the health benefits attributed to ALA supplements are based on lab testing on animals, primarily rats. Whether humans would experience similar results from ALA’s antioxidant powers has not been studied enough to produce definite answers.

Early animal studies suggest that ALA may help in treating Alzheimer’s and other diseases that affect the nervous system [source: Larsen]. Additional studies have shown that a combination of antioxidants (including ALA) has helped cancer patients regain their appetite and weight. While early lab experiments suggest that ALA might cause cancer cells to self-destruct, it is unknown if the same effect can be replicated in animals or humans. Researchers are studying ALA as a possible therapy for reducing the side effects of radiation and chemotherapy. Research is also underway to determine if ALA can help prevent nerve damage that may result from some chemotherapy drugs [source: American Cancer Society].

Another potential benefit of ALA is the treatment of diabetes. Although some studies have found that ALA has a positive effect on insulin sensitivity, glucose metabolism and diabetic neuropathy, more research is needed to determine whether ALA supplements provide substantial benefits for type 2 diabetes and its complications [source: National Center for Complimentary and Alternative Medicine].

ALA supplements may also decrease the buildup of plaque within the arteries. One study found that ALA reduced heart damage caused by chemotherapy drugs. Another found it beneficial in treating cardiovascular autonomic neuropathy — a condition characterized by an irregular heartbeat that’s common in diabetics [source: Higdon, American Cancer Society].

There are also reports that ALA may have health benefits in relation to cataracts, seizures, kidney damage and liver disease, but additional studies are necessary before any definite conclusion is drawn. In addition, ALA, like just about any other medication or supplement, is not without its side effects. Read on to find out more about ALA’s side effects.

(NaturalNews) Alpha Lipoic Acid, also sometimes known as “ALA” or “thioctic acid”, has a great many useful functions in the human body. It is perhaps best known for being a powerful antioxidant, but there are other properties this compound has that may prove useful for improved and preventive health.

One of the unique properties of Alpha Lipoic Acid is its ability to “recycle” other antioxidants, extending their life in the human body. This means that you gain more benefit from the existing antioxidants you take in.

Since most water soluble antioxidants need to be continuously replenished to do what they do best – neutralize free radicals – this makes ALA particularly useful.

This brings us to another unique property of ALA that makes it highly therapeutic. This potent antioxidant happens to be soluble in both water and fat.

This is significant because it is able to neutralize free radicals in every part of the body, including the brain. The ability to dissolve in both fat and water means that this antioxidant has more “free range” to scrub your body for cell-damaging free radicals.

ALA converts glucose into energy more efficiently, and for this reason it may be used as a dietary supplementation to help regulate blood sugar levels.

Several studies have shown that ALA actually helps to keep blood sugar levels low when taken with meals. This is not the only reason it may be helpful for those with diabetes though. Nerve damage and numbness that often accompany diabetes may also benefit from ALA.

There are other bodies of research that show high ALA supplementation helped to mend damage done by strokes and even to help slow down the process of Alzheimer’s. Its apparent ability to facilitate the regeneration of nerve cells has some very promising implications in brain and nerve trauma treatment.

This one-two punch may make this quite the useful addition to diabetics’ health regimens. However, supervision by a health professional would be recommended if you are in fact diabetic. Since Alpha Lipoic Acid further lowers your insulin levels, it may combine with diabetes medications to excessively lower your blood sugar.

ALA supplements are commonly used to support healthy skin as well. In fact, any potent antioxidant is an excellent “internal skin cream”. Antioxidants help keep your skin young, resilient and supple since they help keep healthy skin cells around longer.

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pierre on July 26, 2011

Alpha Lipoic Acid is not a medication, therefore there is no prescribed dose. Those who are familiar with the supplement recommend a daily maintenance dose of between 50mg to 100mg in most cases.

Therapeutic dose: The amount of alpha lipoic acid used in research has ranged from 150-600 mg per day, with 600 mg per day being used to treat diabetic neuropathies and 150 mg per day for glaucoma.

HIV clinical studies have used 300 to 750 mg of alpha lipoic acid per day. However, patients exceeding the maintenance does must do so under the supervision of their physician. Some clinicians have reported that their patients experienced improved energy levels on doses of 500 to 800 mg a day.

Again, it should be remembered that these are suggested doses only. The FDA does not have an established recommended daily requirement for Alpha lipoic acid.

Alpha lipoic acid (ALA) as a health supplement was first introduced to the mainstream market during the late 1980’s/ early 1990’s.

As a chemical compound, structurally, alpha lipoic acid contains sulfur. As such, ALA supplements take the form of yellow, crystalline powder (sulfur is yellow). Alpha lipoic acid supplements are usually sold loose as a powder, in capsule form or pressed into a tablet.

Since the introduction of these supplements, alpha lipoic acid has become increasingly popular with body builders and other people who exercise, in addition to those with medical conditions ALA can be used to help treat. Some suppliers of alpha lipoic supplements claim that it increases performance as it helps the body take glucose from the blood and transfer it into the muscle as at an increased rate.

Whatever the motivation for using alpha lipoic acid, supplements are a convenient way of taking extra ALA than through the diet alone.

Whilst many foods contain alpha lipoic acid, the levels are usually extremely low as are absorption rates.

By taking alpha lipoic acid supplements a higher amount can more easily be consumed and absorbed by the body. Around 30 to 40% of oral doses of alpha lipoic acid are absorbed [13,[14].

Taken as a general health supplement, alpha lipoic acid receives generally positive responses.

One notable comment is that ALA may degrade quickly when exposed to air and light. ALA in powered form should be kept in dark, tight fitting containers or the powder put into capsules.

To increase the degree of absorption, alpha lipoic acid should not be mixed in with a high volume of liquid and should be taken on an empty stomach.

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pierre on July 26, 2011

Acne is a type of skin disease occurring at the sebaceous follicles of the skin. It usually appears on the face, neck and back. The follicles secrete a natural substance, called sebum, and this mixes with dirt and dust. This then causes the follicles and its surrounding tissues to become inflamed. It’s a good thing to know that a such a substance as alpha lipoic acid for acne may hold a solution.



Getting To Know Acne There are two types of acne, either inflammatory or non-inflammatory. For the non-inflammatory type of acne, there is the closed comedo (whitehead) which appears as small, whitish bumps on the surface of the skin. In this case, the plugged follicle does not surface on the skin. There is also the open comedo (blackhead) wherein the plug is slightly darker in appearance, which is due to melanin buildup. This time the plug enlarges and becomes visible on the skin surface.



For the inflammatory acne types there are papule, pustule, nodule or cyst, and acne conglobata. These skin diseases range from a small, pink bump, to an inflamed bump that contains visible pus, to an acne with severe bacterial infection.



What Is Alpha Lipoic Acid? Tagged by some as the “universal” antioxidant, alpha lipoic acid is used widely for its ability to cure and prevent various diseases by neutralizing free radicals in our bodies and protecting the cells from damage. Free radicals are substances that cause damage to the cells. Some common sources of free radicals are fried foods, smoking, exhaust, and pollution.



What Does Alpha Lipoic Acid Do? The main function of the alpha lipoic acid is to boost the levels of gluthathione, which is responsible for dissolving toxic substances in the liver. Alpha lipoic acid can be easily absorbed into the blood stream, and is found in vegetables and meats.



Because alpha lipoic acid is both water and lipid soluble, it is able to reach all portions of the cell. This exceptional ability to work itself within the cell helps the body rid itself of toxins present in the body. It also works effectively in fighting inflammation resulting from acne lesion on a cellular level, curing them before they develop into a more serious type of inflammatory acne.



Another beneficial effect that can be derived out of the alpha lipoic acid is its ability to preserve and protect vitamins C and vitamin E levels in the skin, which can decrease steadily with constant exposure to ultraviolet (UV) radiation.



More Benefits Alpha lipoic acid can boost energy production in aging cells, enhancing their ability to repair cellular damage and expel waste products within the cell. This process has been used to treat aged skin because alpha lipoic acid is made up of 1% lotion.



Another effect of the activity of alpha lipoic acid is its ability to prevent and reverse scar formation due to acne. This is due to the skin renewal properties present in alpha lipoic acid that is why it has been used as an ingredient of facial creams to help diminish scar formation.



These are just some of the benefits that can be derived from alpha lipoic acid for acne, which has been widely used as an acne treatment formula. Clinical studies have also proven that the alpha lipoic acid does not have adverse effects, even at high doses.

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pierre on July 22, 2011

Nerve skin cells have great electric power conditions that will perpetuate nourishing purpose. Mainly because a ingredient in every challenge of neurological fail to function properly along with degeneration that is definitely a matching drop with lack of feeling wireless wind turbine. A cutting edge understand shows that a combo of R-Alpha Lipoic Acid in addition to Acetyl-L-Carnitine1 were being synergistically capable of maintaining sensation problems wireless wind turbine, coupled with the public presence of experimentally prompted Parkinson’s.

When researchers desire to analysis Parkinson’s on critters they cook a pet unit of Parkinson’s from poisoning bed room by using rotenone, a contaminated way to kill pests which may be greatly enthusiastic about the particular energy-producing mitochondria Organelle located in tissue who build ATP or simply chemical type vigor. Equally linked to cellphone signaling, wireless difference, mobile phone departure, wireless advancement, using heme and then steroid ointment activity. of sensory problems tissue. In this research wildlife had been pre-treated just for month by way of ALA not to mention ALC in advance of exposure to rotenone.

The professionals found out that pretreatment with the strong detox busting nutritional vitamins elevated the option of mitochondria Organelle present in tissues the fact that turn out ATP and also element stamina. Moreover involving portable signaling, cell phone differentiation, portable death, cellular increase, as well as heme plus anabolic steroid functionality. towards self-regenerate and a lot reduce the making of ” free radicals ” within just neural body cells. The analysts concluded that this mixture of nutritional value could possibly be a successful in addition to free from danger reduction strategy for Parkinson’s Problems. I would likely add that that anti-aging system of most of these nutritional value will probably cover sensors wellness generally and is one particular great sterile strategy for spirit typically.

(NaturalNews) Throughout history growing older persons have yearned just for a special elixir to enable them to turn back the the hands of time plus reestablish earlier days. Several end up being that it daydream is going to become a. For a new motorola milestone phone analyze, ancient labrador test subjects currently taking a blend of acetyl L-carnitine and then alpha-lipoic acid regained so much of the youngsters and even stamina these people “got as much as do the Macarena”, as per examine movie director Bruce Ames.

The free radical explanation of aging

Scientists studying getting old are determined that him and i years because much of our skin cells and also the Genetic make-up that contain each of our it is partially coupon support problems with a great assault of incredibly reactive element variety these people talk about a free radicals. These types of slack cannons in the body are definitely the end up of standard metabolic methods, producing oxygen a double edged blade. We can’t do without it, yet o2 moreover releases these destructive compound type that can cause havoc with debris and cause people to period.

A mitochondria is actually a microscopic central heater from each cellphone in your body. Mitochondria crank out energy inside of each and every cellular phone simply by getting rid of meals within the reputation of oxygen. Because of this units which have been completely oxigen rich contain a dangerous of vigor. Yet, the necessary oxygen can be the two close friend and additionally foe. The shooting progression ends up revealing the actual mitochondria ourselves that will superior levels of molecular injury. As we grow older, mitochondria grown to be thus affected by just these free radicals construct y lose their capability to function successfully. It makes sense continually diminishing portable electrical power and others maturing. In addition to being much of our muscle get rid of stamina, people become controlled by degenerative illnesses.

Researchers try to look for a tactic to stop mitochondrial deterioration

The investigation, experienced within the August dilemma of Neurochemical Research, passed off on the University or college of Cal. Doctors explored mitochondrial rot away and also oxidative damage by way of considering the adventure of the mitochrondria with the mind of young at heart rats, along with outdated rodents federal with R-alpha lipoic acid in addition to acetyl L-carnitine (LA/ALC).

The neurological mitochondria of the old rodents, in contrast to in which of this adolescent rodents, acquired appreciably more affordable levels of logically provide vitamin antioxidants plus superoxide dismutase (Turf) action. Additionally experienced alot more oxidative damage to fats and then proteins, and then total diminished task. Supplying LA/ALC in to the previous test subjects mostly renovated age-associated mitochondrial deterioration within the levels acquired because of the youthful test subjects. Most of these outcomes piece of content which mitochrondia get rotten is cast as an important role with mental growing old. They also insurance the fact that a mix of nourishing substances intended for mitochrondria can ameliorate mitochondrial rot away through advoiding oxidative harm.

Interest inside LA/ALC happens to be escalating since professionals in the Linus Pauling Company located at Modifies his name Declare University or discovered that pastime, vitality and then cognition will be superior with the help of the actual formula in the diet. Steer addict Tory Hagen suggests that after just simply a period, older mice on your dietary supplement ended up related to twice as dynamic seeing that older mice never compounded, who is adventure is small.

Supplementation utilizing LA/ALC has additionally been shown to elevate the two spatial and also temporary storage area. Mages of human brain solar cells of compounded good old test subjects clearly show a reduced amount of tooth decay. Supposedly, elements which includes LA/ALC either can mask and / or reverse metabolic complications attributed to mobile or portable the aging process and then the genuine oxidative course of action. Individuals demos can be started to work out if thez LA/ALC combination can offer consumers a method to enrich vigor in addition to mental function well to aging. When in fact they will, all the figures of individuals suffering from degenerative medical conditions can be a great deal diminished, plus the mature many years could really end up being the senior hours imagined when it comes to classified ads with regard to retiring company accounts.

The College of Ca . offers copyrighted your LA/ALC mix while a way to increase metabolic process and manage oxidative anxiety. Juvenon, a enterprise based by simply Ames and then Hagen get qualified a certain from your university, and then unveiled the primary edition of the particular pairing. Happily, either R-alpha-lipoic acid and additionally acetyl H carnitine are around every corner as distinguish, non-patented products that could very well be used conjunction.

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pierre on July 22, 2011

The very first time that alpha lipoic acid ended up being noted seeing that very theraputic for people suffering from diabetes is at 1951. By latter part of the Eighties, professionals pointed out that alpha lipoic acid possessed long been missed while a ultra powerful free radical cleansing. It has been proven that will slow-moving older, help look after alongside heart problems, and additionally tone your defense mechanisms (that quarrels to protect against contamination, consisting of colds, virus, pneumonia, malignancy, etcetera). Now, alpha lipoic acid has been shown to improve thought process and recollection work, together with body strength and durability. Sportsmen are convinced that in addition it helps to build durability.

In companion to barefoot currently being a good detox busting itself, alpha lipoic acid likewise seriously adds to the performance all the other free radical cleansing nutritional vitamins, which include vitamins and minerals A, C, and E and also coenzyme Q-10. Believe it or not, alpha lipoic acid have been referred to as the standard and also most suitable cleansing because doing so can be employed in way more components of your whole body as compared to sometimes vitamin E or maybe C will be able to.

It will be nicely noted which usually minerals will be used in the process of most atherosclerosis (hardening of the particular bloodstream). Nutrients C not to mention E and also coenzyme Q-10* are very renowned as well as revered vitamin antioxidants, though most possess boundaries. Because Alpha Lipoic Acid does not have limitations, that is definitely an indispensable vitamin in treating cardiovascular system issues.

Diabetic persons need to be specially enthusiastic to master who alpha lipoic acid data a stripping of blood sugar on the body. Additionally it may be efficiently used by The uk for pretty much Thirty years to treat neurological ruin, among them which a result of diabetes. Alpha lipoic acid saves our own stressed solutions through diabetes, in combination with other demoralizing neurological disorders, including Parkinson’s affliction together with Alzheimer’s. Inside Malaysia, can be a authorized medical treatment for the majority designs of neurological ruin.

Very a small amount of alpha lipoic acid are made by simply the body’s, and it’s really obtained in only really small levels inside pork, kale together with oranges. That wealthiest foundation is definitely the liver; yet, you would have to have Fifty-five lots of various meats the liver so you can get Hundred mg of Alpha Lipoic Acid.

The possible to avoid plus honestly plague number of polluting of the environment within our cutting-edge atmosphere makes adding to together with minerals vital for health and well-being.

Supplementation stands out as the only way to build good amounts of vitamin antioxidant regarding elimination and / or medication of just about any chronic disorder. There aren’t any ugly side effects from Alpha Lipoic Acid. A large number of federal government imply everyone require amongst 50 and then 75 milligrams of Alpha Lipoic Acid each day.

Diabetes and even Alpha Lipoic Acid
Eighty percentage of virtually all diabetes patients are called variety A couple of, and also non-insulin based mostly diabetes patients. Even when sort 2 people suffering from diabetes will need to take the hormone insulin proceedures to live on, variety Couple of people with diabates frequently turn out so much insulin shots as ever. However, the problem in variety Two people with diabetes is because have forfeit a chance to take advantage of his / her insulin.

In get for category Only two people suffering from diabetes to recoup astounding to employ blood insulin, 3 measures are needed:
An individual) Eating alteration: Saturated (trans) fat and delicate mister need to be refrained from at the same time ingesting foods that happen to be very easily metabolized (fruit and veggies).

2) A respectable workout routines: It has to be brisk the right amount of to cause your system to raised implement its blood insulin.

3) Sufficient diet regime by way of the right diet and nutritional vitamin supplements: Even if almost all diabetics really are over weight, they’re malnourished.

The most typical trouble with regard to people suffering from diabetes will be sensation problems damages strongly then heart problems.

Alpha lipoic acid will be indispensable inside improving upon utilising of blood insulin along with slowing down sensory harm.

Nerve ruin right from diabetes results in strength weakness which leads to any unusual heart beat not to mention pins and needles using getting rid of plus significant discomfort, particularly a person. The 1st manifestation of sensory problems destruction through diabetes could very well be shoe fall the result of decline muscular tissues. Blindness, kidney letdown, as well as amputations are required suffering from diabetes side effects which might be attributable to arteriosclerotic disease and even sensors destruction.

There aren’t reliable prescriptions for the treatment of diabetes. But, there happens to be pray. Recent reports are convinced that any free radical cleansing source of nourishment, alpha lipoic acid, can start re-establishing lack of perform only for 5 a few months of increased medication dosage medication.

The to begin with apparent facts who natural cure can certainly turn back neurological destruction done by diabetes was put together by a U . k . organization. Seventy-three style Step 2 people with diabetes provided by ten Languages like german healthcare stores were definitely in the long run preferred and additionally at random allotted to be given sometimes 800/mg of alpha lipoic acid and / or a placebo (sweetener oral treatment). With study’s close (some times), there were appreciable improvement throughout people consuming alpha lipoic acid when absolutely no transformation was first famous from the placebo cluster.

In Michael went bonkers, Diabetes Maintenance experienced which gamma-linolenic acid out of borage, schokohutige currant seed products, or maybe oil and gas of evening hours primrose might limit the always-present bloating in diabetes. Nevertheless, at this point it’s got possibly not acquired prefer by way of traditional medicine. It might be safer to assume alpha lipoic acid will see the very same destiny.

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pierre on July 21, 2011

Peripheral neuropathy is a condition characterized by pain and numbness in the hands and feet that occurs in patients with diabetes, nerve pressure (from abnormal bone growth or a tumor), vitamin deficiency, kidney or liver disease and alcoholism. Cancer treatment chemicals can also cause it and HIV patients are prone to it .

More than 20 percent of diabetic patients develop peripheral neuropathy — the leading cause of lower limb amputation. Oral and intravenous ALA is approved for use in Germany for treatment of diabetic neuropathy and in the U.S., research has shown that ALA may be helpful in treating nerve damage in diabetics and in cancer patients .

In a clinical trial, diabetic patients suffering from peripheral neuropathy who were given 200 mg of ALA intravenously for 21 days reported a reduction in pain. A larger study of diabetics with peripheral neuropathy who were injected with 600 mg of ALA a day for three weeks, followed by 12 weeks of oral supplements, also experienced relief .

A small study in Austria found that more than half of the cancer patients who took ALA after getting the chemotherapy drug oxaliplatin reported an improvement in neuropathy symptoms . The National Cancer Institute is currently conducting a phase-3 study on ALA’s use in preventing peripheral neuropathy in cancer patients undergoing chemotherapy treatment .

Alpha lipoic acid enhances glucose uptake in type 2 diabetes, inhibits glycosylation (the abnormal attachment of sugar to protein), and has been used to improve diabetic nerve damage and reduce pain associated with that nerve damage.

Over the past 20 years, the number of adults diagnosed with diabetes has more than doubled, and children are being diagnosed with diabetes in alarming numbers. Diabetes has rapidly emerged as a leading culprit in the epidemic of heart disease that is sweeping the country, and it is a leading cause of amputation and blindness among adults.

As a powerful antioxidant, alpha lipoic acid positively affects important aspects of diabetes, including blood sugar control and the development of long-term complications such as disease of the heart, kidneys, and small blood vessels.

“Intravenous racemic ALA, a potent antioxidant, rapidly and to a significant and meaningful degree, improved such positive neuropathic sensory symptoms as pain and several other neuropathic end points. This improvement of symptoms was attributed to improved nerve pathophysiology, not to increased nerve fiber degeneration,” the authors write. “Because of its safety profile and its effect on positive neuropathic sensory symptoms and other neuropathic end points, this drug appears to be a useful ancillary treatment for the symptoms of diabetic polyneuropathy.”

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Alpha lipoic acid is featured with a large number of benefits and uses. This is a type of fatty acid, called as ALA which can easily dissolve in both fat and water. One of the greatest benefits of this fatty acid is weight loss and reduction.

Alpha-lipoic acid plays a very important role in the energy production centers of our cells (mitochondria). In recent years, clinical research has suggested that alpha-lipoic acid supplements may have a variety of potential health benefits, including a possible reduction in the risk of cardiovascular disease. Recent laboratory research has also shown that alpha-lipoic acid supplements markedly reduce the incidence of obesity in obesity-prone rats. However, it has not been clear whether or not alpha-lipoic acid has any clinically significant anti-obesity effects in humans. Now, a newly published prospective, randomized, blinded, placebo-controlled clinical research study suggests that alpha-lipoic acid supplementation may indeed improve weight loss in obese humans.

In this study, which appears in the current issue of The American Journal of Medicine, 360 obese patient volunteers were randomized to receive either alpha-lipoic acid supplements or identical-appearing placebo pills. Patients who were assigned to receive alpha-lipoic acid supplements received either 1,200 milligrams of alpha-lipoic acid per day or 1,800 milligrams per day. After 20 weeks, all patient volunteers were weighed once again.

After 20 weeks, the group of patients that had received 1,800 milligrams of alpha-lipoic acid per day experienced a modest but significant reduction in weight (2.1 percent of body weight) when compared the patient volunteers who had received the placebo pills.

While a 2 percent weight loss may sound trivial, it must be emphasized that obesity is an illness that has been shown to be refractory to almost every medical treatment (other than surgery), including the handful of very expensive prescription medications that have been approved by the FDA to treat obesity. Certainly, alpha-lipoic acid, by itself, is not likely to reverse the epidemic of obesity that has spread throughout the world. However, if the findings of this small prospective, randomized, controlled clinical study can be confirmed by larger studies, then alpha-lipoic acid may find use as an adjunct to other weight-loss strategies (including, of course, dieting and exercise).

ALA is the ideal insulin mimic. When glycogen storage is complete and insulin shuttles excessive sugar out in order to change as fat, this alpha lipoic acid mimics the insulin. In this process, the ALA raises glut 4 transporters that are insulin regulated ones. When there is an increase in these transporters, the glucose amount injected into muscle is also raised and there is reduction of fat accumulation. It is further important to note that alpha lipoic acid is not similar to alpha linolenic acid that is the Omega 3 fatty acid useful for heart health. Confusion arises as both are abbreviated as ALA.

Alpha lipoic acid is not generally used for fast weight loss. But consistent and regular use of this fatty acid can help in weight reduction. It will help in increasing the rate in which glucose is taken into the cells and raises the metabolic rate. The outcome is that more energy is utilized in the cells with lesser calories available to be stored as fat. Also, the increased glucose metabolism having resultant reduction in the blood sugar levels will help to prevent storage of all the belly fat. This reduction in fat storage takes place as inadequate glucose leads to increased production of insulin. The elevated levels of insulin then lead to fat storage because of anabolic nature of the insulin.

Various studies have been taken up showing that ALA benefits include protection of the nervous system and enhancement of cognition. Alpha lipoic acid weight loss results have been amazing and effective as well as it improves the ability of the body to reduce fat and add lean mass.

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pierre on March 31, 2011

Alpha lipoic acid, also known as Lipoic acid, is contained inside every cell of the body where it helps produce energy. Lipoic acid also helps change glucose (blood sugar) into energy for the body’s needs, which is especially beneficial for diabetics. As an antioxidant, ALA helps to reduce the effects of naturally occurring chemicals called free radicals. Unlike other antioxidants, however, Lipoic acid is unique in that it works in both water and fat. Other antioxidants, such as vitamin c, only work in water or, such as vitamin e, in fat.

Typical healthy bodies produce enough Lipoic acid and therefore do not require supplemental sources. Unfortunately those with diabetes characteristically have low levels of ALA and are frequently unaware of that fact, given that typical mainstream medical doctors frequently do not test for these levels. In fact, it has been proven that certain nerve diseases, such as diabetic neuropathy are at least partially caused by free radical damage.

Diabetic neuropathy, or diabetic peripheral neuropathy, is a common complication of diabetes. Neuropathy is damage to the nerves that allow you to feel sensations such as pain, numbness, and other symptoms in the extremities, typically the legs and feet. There are a number of ways that diabetes damages the nerves, but they all seem related to blood glucose being too high for a long period of time. Nerve damage is one of diabetes most devastating complications that affect more than 60-70 % of all diabetics according to the National Institute of Diabetes and Digestive and Kidney Diseases. Low calorie foods that taste great are all around us!

Lipoic acid is not new and for decades it has been used in Germany to treat diabetic peripheral neuropathy. A study in Diabetes Care recently reported that alpha lipoic acid may partially restore diabetic nerve function after a high dose oral treatment was given for four months. The theory is that lipoic acid may be able to go into all the parts of a nerve cell and potentially protect it against such damage since it works in both fat and water. Supplementation with lipoic acid has also been suggested by some diabetic specialists and it is being further studied in humans for diabetic neuropathy.

While Alpha lipoic acid is made by the body it can also be found in very small amounts in foods such as spinach, broccoli, peas, Brewer’s yeast, brussel sprouts, rice bran, and organ meats. Alpha lipoic acid supplements are available in capsule form at health food stores, some drugstores, and online.

All foods-carbohydrates, fats, and proteins-are broken down into simple organic chemicals. Once foods are sufficiently processed, they enter the cell and are methodically burned to produce energy. Alpha lipoic acid changes certain chemicals that are required for energy metabolism,

and it provides the means by which these essential substances can enter the mitochondrion. Some scientists believe that increasing the intake of AIA can greatly increase the amount of fuel burned in the cell, thereby augmenting the amount of energy available to your body for tasks such as muscle movement, growth, and repair of tissues.

AIA also appears to have the extraordinary ability to prevent damage to the cell at the genetic level. It changes certain chemicals that are required for energy metabolism, and it provides the means by which these essential substances can enter the mitochondrion. Because ALA is operative in so many basic cellular functions it has a great future as a drug for any number of diseases.

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pierre on March 4, 2011

1、Lipoic Acid is a vitamin B
It is used for the treatment of diabetic neuropathy, or neurological complications of drugs.

2、Lipoic acid is also a super type of anti-oxidants
Known as the “universal antioxidant” is even more radical catcher, is the body’s cells use sugar to produce energy and other energy materials essential nutrient required for a restricted substance, widely used in the treatment and prevention of heart disease, diabetes and other disease. It is generally believed that conservation and regeneration of other antioxidants such as vitamin C and E, and to balance blood sugar levels. It is an effective way to boost the immune system, from the free radical damage. There are treatment of a variety of ailments have: liver disease, diabetes, Human Immunodeficiency carriers, AIDS, psoriasis, eczema, burns, skin cancer, multiple sclerosis, Parkinson’s disease, neurological aspects of disease, rheumatoid disease, rheumatoid arthritis, systemic lupus erythematosus, scleroderma, autoimmune aspects of disease, cataracts and other eye diseases, heart disease, stroke, arteriosclerosis, for acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver disease.

3、It’s a heavy metal chelator
2HLa+ M2 + (divalent metal) ==== 2H + + [M (La) 4] -, a high dielectric constant

4、Lipoic acid can inhibit Alzheimer’s medicines
This cheap lipoic acid drugs auxiliary treatment of diabetes and treatment of Alzheimer’s disease with acetylcholinesterase inhibitors commonly used drugs used to inhibit the onset of patient illness, the patient’s condition and to get some relief.

5、Strong force of lipoic acid
It is involved in energy metabolism, not only to increase the elimination of other antioxidants, free radicals, promote recovery, improve the body’s ability to reduce fat gain muscle, but also improve insulin sensitivity, helping into muscle cells, lipoic acid is one of seven products to block aging nutrition. And it can help to be beauty, to activate cells, to improve hair growth.

The next I will tell you some benefits of alpha lipoic acid

1, the stability of blood glucose
    Since the beginning of the treatment is as diabetes drugs, of course, there will be such a feature. In fact, lipoic acid is primarily to prevent the sugar with the protein binding, that is, the “anti-glycation” role, which allows easily become stable blood glucose levels, so as to improve the former is the metabolism of vitamins, so that patients with liver disease and diabetes taking.
2 strengthen the liver function

    With a lipoic acid can enhance the function of the liver activity, so early was also used as food poisoning or metal poisoning     antidote to use. 3. Recovery fatigue Because lipoic acid can make energy metabolism rate, and effectively eat the food into energy, which can quickly eliminate fatigue, your body feel tired easily.
4 to improve dementia
    Lipoic acid composition of molecules quite small, so a few can reach the nutrition of the brain, the brain has continued to antioxidant activity, but also for improving the dementia is considered to be effective.
5. Protect the body
    In Europe, lipoic acid as an antioxidant specifically to do some research and found that lipoic acid can protect the liver and heart damage, inhibit the occurrence of cancer cells in vivo, and ease the body caused by allergic inflammation, arthritis and asthma.
6. Anti-aging skincare
    LA has amazing antioxidant capacity, can cause skin aging ingredients to remove reactive oxygen species, and because vitamin E than the even smaller molecules, coupled with both water soluble and fat-soluble and is therefore absorbed by the skin very easy. (Widely used in Taiwan, compared with fat-soluble CoQ10, its biggest disadvantage is not easily absorbed) by the dark circles, wrinkles and spots such remarkable performance, combined with strengthening the body’s metabolism will get better blood circulation, skin muddy can improve, the pores have become smaller, delicate skin to become enviable. Therefore, lipoic acid is also No.1 in the United States keep pace with the Q10’s anti-aging nutrients.
    In addition, as long as adequate intake of lipoic acid, you can reach from the body to ultraviolet radiation to minimize damage to the skin can also be caused by the ease with age, skin damage and generate new skin and maintain skin moisture, activating the body’s circulation and improve the physical cold easily.

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