AI have major depression and anxiety. Many forms of alternative therapy were not that helpful to me, but my case is very chronic and probably more treatment-resistant than yours. I am on abilify, lamictal, klonopin and recently stopped taking paxil.

As others have mentioned, exercise can be a very powerful antidepressant. I would rather give up my meds than give up my exercise routine, which I do 6-7 days per week.

There is a good deal of research on the positive effects of Omega-3 oils. If you are a vegetarian, flax seed oil is a good alterative. You can google "omega-3 foods" to find foods that are high in Omega-3. I don't think there is any conflict between taking an antidepressant while taking Omega-3. One shrink suggested my taking Omega-3 oils while I was taking antidepressants.

Some researchers recommend SAM-e, but I and others I know found it to be very expensive and ineffectual.

Amino acids that may help depression include phenylalanine, tyrosine, GABA and theanine.

5-HTP, tryptophan and alpha lipoic acid might have some antidepressant qualities. The same can be said for folic acid and the B vitamins in general.

Since 5-HTP and tryptophan are precursors to serotonin, I would check with a doctor who knows about alternative medicine to find out if it is ok to take these supplements while on Zoloft.

If possible, try to find a doctor or other health professional who knows about natural remedies for depression.

Relaxation techniques, including medication, have helped me deal with depression.

Research suggests that the combination of psychotherapy plus meds is more effective than therapy alone or meds alone.

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